| One-Year Mortality of Acute Kidney Injury in Patients with Acute Myocardial Infarction |
| Dae Hun Lim, M.D., Jong Hyeok Jeong, M.D., Ji Min Jeong, M.D., Chang Seong Kim, M.D., Joon Seok Choi, M.D., Jeong Woo Park, M.D., Eun Hui Bae, M.D., Seong Kwon Ma, M.D. and Soo Wan Kim, M.D. |
| Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea |
| 원저 : One-Year Mortality of Acute Kidney Injury in Patients with Acute Myocardial Infarction |
| Dae Hun Lim, M.D., Jong Hyeok Jeong, M.D., Ji Min Jeong, M.D., Chang Seong Kim, M.D., Joon Seok Choi, M.D., Jeong Woo Park, M.D., Eun Hui Bae, M.D., Seong Kwon Ma, M.D. and Soo Wan Kim, M.D. |
| Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea |
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| Abstract |
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Purpose: Acute kidney injury (AKI) is a common complication during hospitalization and is an accepted risk factor for in-hospital mortality. However, the association of severity of AKI with the long-term risk of death is not well known. This study aimed to investigate the incidence and clinical significance of AKI in patients with acute myocardial infarction (AMI).
Methods: To examine the effect of the severity of AKI on 1-year risk of death following AMI, we performed an observational study of 1,224 patients admitted for AMI. We evaluated the association between AKI and all-cause mortality. Patients with maintaining hemodialysis treatment (n=7), and who died during hospitalization (n=71) were excluded. Remaining 1146 patients were divided into three groups according to the Acute Kidney Injury Network (AKIN) criteria (Stage-1, -2, and-3). The primary end point of the study was 1-year all-cause mortality after hospital discharge. The relation between the severity of AKI and 1-year mortality after AMI was analyzed.
Results: AKI was developed in 222/1,146 (19.3%) patients during the hospital stay. Adjusted hazard ratio for 1-year mortality was 3.064 (95% CI 1.618 to 5.803, p=0.001), 6.112 (95% CI 2.344 to 15.935, p<0.001) and 20.030 (95% CI 5.428 to 73.912, p<0.001) in stage-1, -2, and stage-3 AKI groups
compared with that of no AKI group.
Conclusion: The severity of AKI is strongly related to 1-year all cause mortality in patients with AMI. |
| Key Words:
Acute kidney failure, Myocardial infarction, Fatal outcome |
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